Bidirectional transport of interleukin-1 alpha across the blood-brain barrier
WA Banks, AJ Kastin, DA Durham - Brain research bulletin, 1989 - Elsevier
Abstract Circulating interleukin-1 alpha (IL-1α) has multiple effects on the central nervous
system. We investigated the ability of radioiodinated IL-1α (rIL-1α) to cross the rodent blood-
brain barrier and found its entry rate to be 43.9 times greater than that predicted by leakage
alone. The rIL-1α entered multiple regions of the brain, with over 40% entering at the cortex.
The hypothalamus had the highest entry rate on a weight basis but only accounted for 2% of
total entry. In all experiments, the entry rate of rIL-1α greatly exceeded that of simultaneously …
system. We investigated the ability of radioiodinated IL-1α (rIL-1α) to cross the rodent blood-
brain barrier and found its entry rate to be 43.9 times greater than that predicted by leakage
alone. The rIL-1α entered multiple regions of the brain, with over 40% entering at the cortex.
The hypothalamus had the highest entry rate on a weight basis but only accounted for 2% of
total entry. In all experiments, the entry rate of rIL-1α greatly exceeded that of simultaneously …
